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In 1645 the Japanese samurai Musashi Miamoto wrote A Book of Five Rings, which described the attitudes necessary for individual success. Though he was a swordsman, his book was not limited to combat but addressed the much broader question of how to achieve excellence in life through study, discipline, and planning. It is still avidly read in Japan today.
Arthur Kornberg's book is a modern-day Book of Five Rings that replaces the medium of swordsmanship with that of biochemistry, particularly enzymology. As Kornberg describes his successive research problems, the challenges they presented, and the ultimate accomplishments that resulted, he provides us with a primer in the strategies needed to do scientific work of great significance. Moreover, these strategies are played out in the context of solving some of the great biochemical problems of the twentieth century.
The ability to manipulate and alter DNA fired a revolution that forever changed the nature of biology. Arthur Kornberg is a primary architect of that revolution, arguably one of the two or three most important biologists of this time. Prior to Kornberg, genetic information and later DNA were imbued by biologists with an almost vitalistic aura. Kornberg demonstrated that DNA is a molecule synthesized by enzymes, like all other chemical constituents of the cell. More important, he trained a school of scientists who focused on and discovered many of the enzymatic activities that act on DNA. It is these enzymes in particular that allow modern "genetic engineering."
For the Love of Enzymes does not describe a single lucky or hard-won accomplishment. Rather, it is the story of thirty years of decisive campaigns, nearly all of which led to insights of major significance. In relating his story, Kornberg never avoids the difficult question of "why": why he felt classical nutritional studies had reached a plateau, why he turned to enzymology as a discipline in which the important answers would be found, and why he believes the study of enzymes will grow ever more important as we face the new scientific frontier of brain function.
This book will challenge students of biology and chemistry at all levels who want to do important work rather than simply follow popular trends. It will also delight and inform readers who wish to understand how "real" science is done, and to learn of the values that guide one of our greatest researchers.
- Sales Rank: #907230 in Books
- Brand: Brand: Harvard University Press
- Published on: 1991-09-01
- Released on: 1991-10-01
- Original language: English
- Number of items: 1
- Dimensions: 9.25" h x .88" w x 6.13" l, 1.10 pounds
- Binding: Paperback
- 352 pages
- Used Book in Good Condition
From Library Journal
Claiming he has never met a "dull enzyme," Kornberg has devoted his life to pursuing and purifying these critical protein molecules. Awarded the Nobel Prize (with Severo Ochoa) in 1959 for his work on DNA synthesis, Kornberg has also played a principal role in the establishment of Stanford's biochemistry department and has produced two major volumes on DNA synthesis and replication. This account traces a history of achievement in biochemistry by many dedicated individuals and makes a strong case for basic biochemical research. While Kornberg writes clearly and convincingly about his genuine and total fascination for enzymes, the descriptions of significant experiments will be intelligible only to students or professionals in the field. The book is most appropriate, therefore, for academic collections.
- Laurie Bartolini, Lincoln Lib., Springfield, Ill.
Copyright 1989 Reed Business Information, Inc.
Review
Kornberg is a gifted writer and the book contains sentences of both wisdom and beauty...For the Love of Enzymes is at the same time charming, stimulating and informative, a reflection of its author. If widely read--and I very much hope it is--it will greatly contribute to the scientific education of the public. (Efraim Racker Nature)
A well-written history of the field and Kornberg's role in it, full of explanations of the science itself and clear-eyed observations about the process of research. Readers will find here the first-rate mind of a first-rate scientist, and there is pleasure in that. It is rare to read such a lucid account of epoch-making science. (Lee Dembart Los Angeles Times)
Kornberg's book shines with a love of science...Let us hope that there are those like him today who will, in 50 years' time, be able to inform, instruct and amaze us with a book such as this. (Maxine Clarke New Scientist)
This is the life of a great scientist, told with modesty and wit. (Peter Gorner Chicago Tribune)
Kornberg's new book For the Love of Enzymes...traces the origins and development of his research on the biosynthesis of DNA, work that was to bring him a Nobel Prize in 1959. Although largely devoted to science, the book is written from a distinctly personal point of view, which adds greatly to its interest not only because of what we learn about Kornberg the man but also because of the light it sheds on how the personality of a researcher may be reflected in the style of his work...The fusion of biochemistry and genetics that has led to the dramatic emergence of molecular biology and genetic engineering in the past few decades is perhaps the most notable event in science in the later 20th century. For the Love of Enzymes offers a unique and fascinating insight into the life and thought of a man whose work was at the center of these grand developments. (Eugene Kennedy Science)
This is a first-rate book. I had difficulty in putting it down. Kornberg is refreshingly frank and writes with a lively wit as well. It has a wealth of important biochemical facts and history, which are brought to life with clarity and style. The book is a paradigm for how to convey factual information in a way that is easy to remember and to enjoy. (Paul Schimmel, Massachusetts Institute of Technology)
From the Back Cover
The ability to manipulate and alter DNA fired a revolution that forever changed the nature of biology.
Most helpful customer reviews
2 of 2 people found the following review helpful.
ENZYMES CREATE LIFE
By Wilfred Desaulnier
The importance of enzymes was first impressed on me years ago (1981) by Dr. William Donald Kelley through his explanation and use of pancreatic enzymes in his cancer treatment protocol One Answer To Cancer an Ecological Approach To TH. (More recent accounts of Dr. Kelley's protocol are presented in Cancer: Curing the Incurable Without Surgery, Chemotherapy, or Radiation and One Man Alone: An Investigation of Nutrition, Cancer, and William Donald Kelley) Around 1998 I came across and read the classic "Enzyme Nutrition" by Dr. Edward Howell Enzyme Nutrition which imparted to me the vital importance of enzymes to the essence of life. As a consequence, I always strive to eat raw foods as much as possible and to take digestive enzymes regularly based on these teachings.
However, I have always been intrigued by the mystery of when and how life is born (erupts) from inanimate matter and the hints were that enzymes played a key role in that evolutionary step. In my recent book searches I came across Arthur Kornberg's "For the Love of Enzymes" and bought it on the basis of the recommendations with the hope that it might shed some light on the process of the eruption of life.
I was captivated by the book and could not put it down until finished. It clearly defined what an enzyme was in chemical terms. It certainly confirmed to me that life would not exist were it not for enzymes. Although the explicit details of the step by step process of the evolution of first life still remains to be unveiled (to my present knowledge), there remains no doubt in my mind that enzymes are the vital "spark" which makes and keeps the "engine" of life going. This book has filled many gaps in my pseudo-layman's knowledge of life, biology, and health. In addition, it gives the insight into the form, creation and manipulation of DNA for which enzymes are essential, and the resultant techniques of genetic engineering. It also presents an inspiring account of the pursuit of science from one very prominent person's (Nobel recipient's) perspective. I highly recommend this book to any layman interested in the origin of life, biology, and health - and certainly any aspiring health practitioner or student in the health field or the broad field of biology, chemistry, and biochemistry. It was mind-expanding and mind-blowing to me! Enjoy!
1 of 1 people found the following review helpful.
Surprising
By Maceo
I was expecting a dry textbook-like experience.
Fortunately, there was so much more. Insights into the lab, their work habits, personal lives and science makes this book an enticing read.
0 of 0 people found the following review helpful.
Five Stars
By xiang ma
good
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